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DNA promoter hypermethylation of melanocyte lineage genes determines melanoma phenotype
Cellular stress contributes to the capacity of melanoma cells to undergo phenotype switching into highly migratory and drug-tolerant dedifferentiated states. Such dedifferentiated melanoma cell states are marked by loss of melanocyte-specific gene expression and increase of mesenchymal markers. Two...
Autores principales: | Sanna, Adriana, Phung, Bengt, Mitra, Shamik, Lauss, Martin, Choi, Jiyeon, Zhang, Tongwu, Njauw, Ching-Ni, Cordero, Eugenia, Harbst, Katja, Rosengren, Frida, Cabrita, Rita, Johansson, Iva, Isaksson, Karolin, Ingvar, Christian, Carneiro, Ana, Brown, Kevin, Tsao, Hensin, Andersson, My, Pietras, Kristian, Jönsson, Göran |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Clinical Investigation
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675437/ https://www.ncbi.nlm.nih.gov/pubmed/36040798 http://dx.doi.org/10.1172/jci.insight.156577 |
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