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The applications of machine learning to predict the forming of chemically stable amorphous solid dispersions prepared by hot-melt extrusion
Amorphous solid dispersion (ASD) is one of the most important strategies to improve the solubility and dissolution rate of poorly water-soluble drugs. As a widely used technique to prepare ASDs, hot-melt extrusion (HME) provides various benefits, including a solvent-free process, continuous manufact...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9925947/ https://www.ncbi.nlm.nih.gov/pubmed/36798832 http://dx.doi.org/10.1016/j.ijpx.2023.100164 |