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Initial spindle positioning at the oocyte center protects against incorrect kinetochore-microtubule attachment and aneuploidy in mice

Spindle positioning within the oocyte must be tightly regulated. In mice, the spindle is predominantly assembled at the oocyte center before its migration toward the cortex to achieve the highly asymmetric division, a characteristic of female meiosis. The significance of the initial central position...

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Detalles Bibliográficos
Autores principales: Kincade, Jessica N., Hlavacek, Avery, Akera, Takashi, Balboula, Ahmed Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9937575/
https://www.ncbi.nlm.nih.gov/pubmed/36800430
http://dx.doi.org/10.1126/sciadv.add7397