Enzymatic Hydroxylation of Aliphatic C-H Bonds by a Mn/Fe Cofactor

Manganese cofactors activate strong chemical bonds in many essential enzymes. Yet very few manganese-dependent enzymes are known to functionalize ubiquitous carbon-hydrogen (C-H) bonds, and those that catalyze this important reaction display limited intrinsic reactivity. Herein, we report that the 2...

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Detalles Bibliográficos
Autores principales: Powell, Magan M., Rao, Guodong, Britt, R. David, Rittle, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10029006/
https://www.ncbi.nlm.nih.gov/pubmed/36945426
http://dx.doi.org/10.1101/2023.03.10.532131