Mechanistic insights into the aggregation pathway of the patient-derived immunoglobulin light chain variable domain protein FOR005

Systemic antibody light chain (AL) amyloidosis is characterized by deposition of amyloid fibrils. Prior to fibril formation, soluble oligomeric AL protein has a direct cytotoxic effect on cardiomyocytes. We focus on the patient derived λ-III AL variable domain FOR005 which is mutated at five positio...

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Detalles Bibliográficos
Autores principales: Pradhan, Tejaswini, Sarkar, Riddhiman, Meighen-Berger, Kevin M., Feige, Matthias J., Zacharias, Martin, Reif, Bernd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10290123/
https://www.ncbi.nlm.nih.gov/pubmed/37353525
http://dx.doi.org/10.1038/s41467-023-39280-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10290123/
https://www.ncbi.nlm.nih.gov/pubmed/37353525
http://dx.doi.org/10.1038/s41467-023-39280-0

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