DNA polymerase ε leading strand signature mutations result from defects in its proofreading activity

The evidence that purified pol2-M644G DNA polymerase (Pol)ε exhibits a highly elevated bias for forming T:dTTP mispairs over A:dATP mispairs and that yeast cells harboring this Polε mutation accumulate A > T signature mutations in the leading strand have been used to assign a role for Polε in rep...

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Detalles Bibliográficos
Autores principales: Johnson, Robert E., Prakash, Louise, Prakash, Satya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371845/
https://www.ncbi.nlm.nih.gov/pubmed/37307920
http://dx.doi.org/10.1016/j.jbc.2023.104913

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371845/
https://www.ncbi.nlm.nih.gov/pubmed/37307920
http://dx.doi.org/10.1016/j.jbc.2023.104913

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