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Pck1 Gene Silencing in the Liver Improves Glycemia Control, Insulin Sensitivity, and Dyslipidemia in db/db Mice
OBJECTIVE—Cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C; encoded by Pck1) catalyzes the first committed step in gluconeogenesis. Extensive evidence demonstrates a direct correlation between PEPCK-C activity and glycemia control. Therefore, we aimed to evaluate the metabolic impact and their u...
Autores principales: | Gómez-Valadés, Alicia G., Méndez-Lucas, Andrés, Vidal-Alabró, Anna, Blasco, Francese X., Chillon, Miguel, Bartrons, Ramon, Bermúdez, Jordi, Perales, José C. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2494684/ https://www.ncbi.nlm.nih.gov/pubmed/18443203 http://dx.doi.org/10.2337/db07-1087 |
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