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Simplification of biochemical models: a general approach based on the analysis of the impact of individual species and reactions on the systems dynamics
BACKGROUND: Given the complex mechanisms underlying biochemical processes systems biology researchers tend to build ever increasing computational models. However, dealing with complex systems entails a variety of problems, e.g. difficult intuitive understanding, variety of time scales or non-identif...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349553/ https://www.ncbi.nlm.nih.gov/pubmed/22390191 http://dx.doi.org/10.1186/1752-0509-6-14 |