The Integrated Web Portal for Escalation with Overdose Control (EWOC)
In this paper, we present the design and implementation of a novel web portal for the cancer phase I clinical trial design method Escalation with Overdose Control (EWOC). The web portal has two major components: a web-based dose finding calculator; and a standalone and downloadable dose finding soft...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Bentham Open
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706802/ https://www.ncbi.nlm.nih.gov/pubmed/23847696 http://dx.doi.org/10.2174/1874431120130427001 |
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author | Wang, Haibin Tighiouart, Mourad Huang, Shao-Chi Berel, Dror Cook-Wiens, Galen Bresee, Catherine Li, Quanlin Rogatko, André |
author_facet | Wang, Haibin Tighiouart, Mourad Huang, Shao-Chi Berel, Dror Cook-Wiens, Galen Bresee, Catherine Li, Quanlin Rogatko, André |
author_sort | Wang, Haibin |
collection | PubMed |
description | In this paper, we present the design and implementation of a novel web portal for the cancer phase I clinical trial design method Escalation with Overdose Control (EWOC). The web portal has two major components: a web-based dose finding calculator; and a standalone and downloadable dose finding software which can be installed on Windows operating systems. The web-based dose finding calculator uses industry standards and is a database-driven and distributed computing platform for designing and conducting dose finding in cancer phase I clinical trials utilizing EWOC methodology. The web portal is developed using open source software: PHP, JQuery, R and OpenBUGS. It supports any standard browsers with internet connection. The web portal can be accessed at: http://biostatistics.csmc.edu. |
format | Online Article Text |
id | pubmed-3706802 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Bentham Open |
record_format | MEDLINE/PubMed |
spelling | pubmed-37068022013-07-11 The Integrated Web Portal for Escalation with Overdose Control (EWOC) Wang, Haibin Tighiouart, Mourad Huang, Shao-Chi Berel, Dror Cook-Wiens, Galen Bresee, Catherine Li, Quanlin Rogatko, André Open Med Inform J Article In this paper, we present the design and implementation of a novel web portal for the cancer phase I clinical trial design method Escalation with Overdose Control (EWOC). The web portal has two major components: a web-based dose finding calculator; and a standalone and downloadable dose finding software which can be installed on Windows operating systems. The web-based dose finding calculator uses industry standards and is a database-driven and distributed computing platform for designing and conducting dose finding in cancer phase I clinical trials utilizing EWOC methodology. The web portal is developed using open source software: PHP, JQuery, R and OpenBUGS. It supports any standard browsers with internet connection. The web portal can be accessed at: http://biostatistics.csmc.edu. Bentham Open 2013-05-31 /pmc/articles/PMC3706802/ /pubmed/23847696 http://dx.doi.org/10.2174/1874431120130427001 Text en © Wang et al.; Licensee Bentham Open. http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited. |
spellingShingle | Article Wang, Haibin Tighiouart, Mourad Huang, Shao-Chi Berel, Dror Cook-Wiens, Galen Bresee, Catherine Li, Quanlin Rogatko, André The Integrated Web Portal for Escalation with Overdose Control (EWOC) |
title | The Integrated Web Portal for Escalation with Overdose Control (EWOC) |
title_full | The Integrated Web Portal for Escalation with Overdose Control (EWOC) |
title_fullStr | The Integrated Web Portal for Escalation with Overdose Control (EWOC) |
title_full_unstemmed | The Integrated Web Portal for Escalation with Overdose Control (EWOC) |
title_short | The Integrated Web Portal for Escalation with Overdose Control (EWOC) |
title_sort | integrated web portal for escalation with overdose control (ewoc) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706802/ https://www.ncbi.nlm.nih.gov/pubmed/23847696 http://dx.doi.org/10.2174/1874431120130427001 |
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