The Integrated Web Portal for Escalation with Overdose Control (EWOC)

In this paper, we present the design and implementation of a novel web portal for the cancer phase I clinical trial design method Escalation with Overdose Control (EWOC). The web portal has two major components: a web-based dose finding calculator; and a standalone and downloadable dose finding soft...

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Detalles Bibliográficos
Autores principales: Wang, Haibin, Tighiouart, Mourad, Huang, Shao-Chi, Berel, Dror, Cook-Wiens, Galen, Bresee, Catherine, Li, Quanlin, Rogatko, André
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Open 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706802/
https://www.ncbi.nlm.nih.gov/pubmed/23847696
http://dx.doi.org/10.2174/1874431120130427001
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author Wang, Haibin
Tighiouart, Mourad
Huang, Shao-Chi
Berel, Dror
Cook-Wiens, Galen
Bresee, Catherine
Li, Quanlin
Rogatko, André
author_facet Wang, Haibin
Tighiouart, Mourad
Huang, Shao-Chi
Berel, Dror
Cook-Wiens, Galen
Bresee, Catherine
Li, Quanlin
Rogatko, André
author_sort Wang, Haibin
collection PubMed
description In this paper, we present the design and implementation of a novel web portal for the cancer phase I clinical trial design method Escalation with Overdose Control (EWOC). The web portal has two major components: a web-based dose finding calculator; and a standalone and downloadable dose finding software which can be installed on Windows operating systems. The web-based dose finding calculator uses industry standards and is a database-driven and distributed computing platform for designing and conducting dose finding in cancer phase I clinical trials utilizing EWOC methodology. The web portal is developed using open source software: PHP, JQuery, R and OpenBUGS. It supports any standard browsers with internet connection. The web portal can be accessed at: http://biostatistics.csmc.edu.
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spelling pubmed-37068022013-07-11 The Integrated Web Portal for Escalation with Overdose Control (EWOC) Wang, Haibin Tighiouart, Mourad Huang, Shao-Chi Berel, Dror Cook-Wiens, Galen Bresee, Catherine Li, Quanlin Rogatko, André Open Med Inform J Article In this paper, we present the design and implementation of a novel web portal for the cancer phase I clinical trial design method Escalation with Overdose Control (EWOC). The web portal has two major components: a web-based dose finding calculator; and a standalone and downloadable dose finding software which can be installed on Windows operating systems. The web-based dose finding calculator uses industry standards and is a database-driven and distributed computing platform for designing and conducting dose finding in cancer phase I clinical trials utilizing EWOC methodology. The web portal is developed using open source software: PHP, JQuery, R and OpenBUGS. It supports any standard browsers with internet connection. The web portal can be accessed at: http://biostatistics.csmc.edu. Bentham Open 2013-05-31 /pmc/articles/PMC3706802/ /pubmed/23847696 http://dx.doi.org/10.2174/1874431120130427001 Text en © Wang et al.; Licensee Bentham Open. http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Wang, Haibin
Tighiouart, Mourad
Huang, Shao-Chi
Berel, Dror
Cook-Wiens, Galen
Bresee, Catherine
Li, Quanlin
Rogatko, André
The Integrated Web Portal for Escalation with Overdose Control (EWOC)
title The Integrated Web Portal for Escalation with Overdose Control (EWOC)
title_full The Integrated Web Portal for Escalation with Overdose Control (EWOC)
title_fullStr The Integrated Web Portal for Escalation with Overdose Control (EWOC)
title_full_unstemmed The Integrated Web Portal for Escalation with Overdose Control (EWOC)
title_short The Integrated Web Portal for Escalation with Overdose Control (EWOC)
title_sort integrated web portal for escalation with overdose control (ewoc)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706802/
https://www.ncbi.nlm.nih.gov/pubmed/23847696
http://dx.doi.org/10.2174/1874431120130427001
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