PKCθ Regulates T-Cell Leukemia-Initiating Activity via Reactive Oxygen Species
Reactive oxygen species (ROS), a by-product of cellular metabolism, damage intracellular macromolecules and, in excess, can promote normal hematopoietic stem cell differentiation and exhaustion(1–3). However, mechanisms that regulate ROS levels in leukemia-initiating cells (LICs) and the biological...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738873/ https://www.ncbi.nlm.nih.gov/pubmed/23086478 http://dx.doi.org/10.1038/nm.2960 |