Cargando…
Bidirectional coupling between integrin-mediated signaling and actomyosin mechanics explains matrix-dependent intermittency of leading-edge motility
Animal cell migration is a complex process characterized by the coupling of adhesion, cytoskeletal, and signaling dynamics. Here we model local protrusion of the cell edge as a function of the load-bearing properties of integrin-based adhesions, actin polymerization fostered by adhesion-mediated sig...
Autores principales: | Welf, Erik S., Johnson, Heath E., Haugh, Jason M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society for Cell Biology
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861089/ https://www.ncbi.nlm.nih.gov/pubmed/24152734 http://dx.doi.org/10.1091/mbc.E13-06-0311 |
Ejemplares similares
-
Stochastic Model of Integrin-Mediated Signaling and Adhesion Dynamics at the Leading Edges of Migrating Cells
por: Cirit, Murat, et al.
Publicado: (2010) -
Probabilistic modeling and analysis of the effects of extra-cellular matrix density on the sizes, shapes, and locations of integrin clusters in adherent cells
por: Welf, Erik S, et al.
Publicado: (2011) -
Integrin-dependent actomyosin contraction regulates epithelial cell scattering
por: de Rooij, Johan, et al.
Publicado: (2005) -
Diverse integrin adhesion stoichiometries caused by varied actomyosin activity
por: Bulgakova, Natalia A., et al.
Publicado: (2017) -
Prion Protein at the Leading Edge: Its Role in Cell Motility
por: Prado, Mariana Brandão, et al.
Publicado: (2020)