Cargando…
Improved metabolic phenotype of hypothalamic PTP1B-deficiency is dependent upon the leptin receptor()
Protein tyrosine phosphatase 1B (PTP1B) is a known regulator of central metabolic signaling, and mice with whole brain-, leptin receptor (LepRb) expressing cell-, or proopiomelanocortin neuron-specific PTP1B-deficiency are lean, leptin hypersensitive, and display improved glucose homeostasis. Howeve...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2014
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986631/ https://www.ncbi.nlm.nih.gov/pubmed/24749060 http://dx.doi.org/10.1016/j.molmet.2014.01.008 |