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Improved HSC reconstitution and protection from inflammatory stress and chemotherapy in mice lacking granzyme B

The serine protease granzyme B (GzmB) is stored in the granules of cytotoxic T and NK cells and facilitates immune-mediated destruction of virus-infected cells. In this study, we use genetic tools to report novel roles for GzmB as an important regulator of hematopoietic stem cell (HSC) function in r...

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Detalles Bibliográficos
Autores principales:	Carnevalli, Larissa S., Scognamiglio, Roberta, Cabezas-Wallscheid, Nina, Rahmig, Susann, Laurenti, Elisa, Masuda, Kohei, Jöckel, Lars, Kuck, Andrea, Sujer, Stefanie, Polykratis, Apostolos, Erlacher, Miriam, Pasparakis, Manolis, Essers, Marieke A.G., Trumpp, Andreas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2014
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010905/ https://www.ncbi.nlm.nih.gov/pubmed/24752302 http://dx.doi.org/10.1084/jem.20131072

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