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CD4(+) T Cells Modified by the Endoribonuclease MazF Are Safe and Can Persist in SHIV-infected Rhesus Macaques
MazF, an endoribonuclease encoded by Escherichia coli, specifically cleaves the ACA (adenine–cytosine–adenine) sequence of single-stranded RNAs. Conditional expression of MazF under the control of the HIV-1 LTR promoter rendered CD4(+) T cells resistant to HIV-1 replication without affecting cell gr...
Autores principales: | Saito, Naoki, Chono, Hideto, Shibata, Hiroaki, Ageyama, Naohide, Yasutomi, Yasuhiro, Mineno, Junichi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078760/ https://www.ncbi.nlm.nih.gov/pubmed/24914931 http://dx.doi.org/10.1038/mtna.2014.20 |
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