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Phosphorylation and SCF-mediated degradation regulate CREB-H transcription of metabolic targets

CREB‑H, an endoplasmic reticulum–anchored transcription factor, plays a key role in regulating secretion and in metabolic and inflammatory pathways, but how its activity is modulated remains unclear. We examined processing of the nuclear active form and identified a motif around S87–S90 with homolog...

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Detalles Bibliográficos
Autores principales: Barbosa, Sónia, Carreira, Suzanne, Bailey, Daniel, Abaitua, Fernando, O'Hare, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571331/
https://www.ncbi.nlm.nih.gov/pubmed/26108621
http://dx.doi.org/10.1091/mbc.E15-04-0247