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In vitro evidence for senescent multinucleated melanocytes as a source for tumor-initiating cells
Oncogenic signaling in melanocytes results in oncogene-induced senescence (OIS), a stable cell-cycle arrest frequently characterized by a bi- or multinuclear phenotype that is considered as a barrier to cancer progression. However, the long-sustained conviction that senescence is a truly irreversibl...
Autores principales: | Leikam, C, Hufnagel, A L, Otto, C, Murphy, D J, Mühling, B, Kneitz, S, Nanda, I, Schmid, M, Wagner, T U, Haferkamp, S, Bröcker, E-B, Schartl, M, Meierjohann, S |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650540/ https://www.ncbi.nlm.nih.gov/pubmed/25837487 http://dx.doi.org/10.1038/cddis.2015.71 |
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