A functional SUMO-motif in the active site of PIM1 promotes its degradation via RNF4, and stimulates protein kinase activity

The PIM1 serine/threonine protein kinase mediates growth factor and survival signalling, and cooperates potently with c-MYC during tumorigenesis. PIM1 is overexpressed in many human cancers and is a promising target for drug development. PIM1 levels are regulated mainly through cytokine-induced tran...

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Detalles Bibliográficos
Autores principales: Iyer, R. Sumanth, Chatham, Lynsey, Sleigh, Roger, Meek, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472562/
https://www.ncbi.nlm.nih.gov/pubmed/28620180
http://dx.doi.org/10.1038/s41598-017-03775-w