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A functional SUMO-motif in the active site of PIM1 promotes its degradation via RNF4, and stimulates protein kinase activity
The PIM1 serine/threonine protein kinase mediates growth factor and survival signalling, and cooperates potently with c-MYC during tumorigenesis. PIM1 is overexpressed in many human cancers and is a promising target for drug development. PIM1 levels are regulated mainly through cytokine-induced tran...
Autores principales: | Iyer, R. Sumanth, Chatham, Lynsey, Sleigh, Roger, Meek, David W. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472562/ https://www.ncbi.nlm.nih.gov/pubmed/28620180 http://dx.doi.org/10.1038/s41598-017-03775-w |
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