Downregulation of macrophage Irs2 by hyperinsulinemia impairs IL-4-indeuced M2a-subtype macrophage activation in obesity

M2a-subtype macrophage activation is known to be impaired in obesity, although the underlying mechanisms remain poorly understood. Herein, we demonstrate that, the IL-4/Irs2/Akt pathway is selectively impaired, along with decreased macrophage Irs2 expression, although IL-4/STAT6 pathway is maintaine...

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Detalles Bibliográficos
Autores principales: Kubota, Tetsuya, Inoue, Mariko, Kubota, Naoto, Takamoto, Iseki, Mineyama, Tomoka, Iwayama, Kaito, Tokuyama, Kumpei, Moroi, Masao, Ueki, Kohjiro, Yamauchi, Toshimasa, Kadowaki, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242852/
https://www.ncbi.nlm.nih.gov/pubmed/30451856
http://dx.doi.org/10.1038/s41467-018-07358-9

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