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c‐Jun NH(2)‐Terminal Protein Kinase Phosphorylates the Nrf2‐ECH Homology 6 Domain of Nuclear Factor Erythroid 2–Related Factor 2 and Downregulates Cytoprotective Genes in Acetaminophen‐Induced Liver Injury in Mice

BACKGROUND AND AIMS: Acetaminophen (APAP) overdose induces severe liver injury and hepatic failure. While the activation of c‐Jun NH(2)‐terminal kinase (JNK) has been implicated as a mechanism in APAP‐induced liver injury, the hepatic defense system controlled by nuclear factor erythroid 2–related f...

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Detalles Bibliográficos
Autores principales:	Chen, Yiping, Liu, Kaihua, Zhang, Jingwen, Hai, Yan, Wang, Peng, Wang, Hongyan, Liu, Qiuyan, Wong, Catherine C.L., Yao, Jun, Gao, Yang, Liao, Yijiao, Tang, Xiuwen, Wang, Xiu Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318587/ https://www.ncbi.nlm.nih.gov/pubmed/31945188 http://dx.doi.org/10.1002/hep.31116

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