High Interferon Signature Leads to Increased STAT1/3/5 Phosphorylation in PBMCs From SLE Patients by Single Cell Mass Cytometry

The establishment of an “interferon (IFN) signature” to subset SLE patients on disease severity has led to therapeutics targeting IFNα. Here, we investigate IFN signaling in SLE using multiplexed protein arrays and single cell cytometry by time of flight (CyTOF). First, the IFN signature for SLE pat...

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Detalles Bibliográficos
Autores principales: Yiu, Gloria, Rasmussen, Tue Kruse, Tsai, Brandon L., Diep, Vivian K., Haddon, David J., Tsoi, Jennifer, Miller, Gopika D., Comin-Anduix, Begoña, Deleuran, Bent, Crooks, Gay M., Utz, Paul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851522/
https://www.ncbi.nlm.nih.gov/pubmed/35185925
http://dx.doi.org/10.3389/fimmu.2022.833636

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