Endocytosed HIV-1 Envelope Glycoprotein Traffics to Rab14(+) Late Endosomes and Lysosomes to Regulate Surface Levels in T-Cell Lines

Production of infectious HIV-1 particles requires incorporation of the viral envelope glycoprotein (Env) at the plasma membrane (PM) of infected CD4(+) T cells. Env trafficking to the PM exposes viral epitopes that can be exploited by the host immune system; however, HIV-1 can evade this response by...

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Detalles Bibliográficos
Autores principales: Hoffman, Huxley K., Aguilar, Rebekah S., Clark, Austin R., Groves, Nicholas S., Pezeshkian, Nairi, Bruns, Merissa M., van Engelenburg, Schuyler B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Virus-Cell Interactions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327703/
https://www.ncbi.nlm.nih.gov/pubmed/35770989
http://dx.doi.org/10.1128/jvi.00767-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327703/
https://www.ncbi.nlm.nih.gov/pubmed/35770989
http://dx.doi.org/10.1128/jvi.00767-22

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