Dose/exposure–response modeling in dose titration trials: Overcoming the titration paradox

Response‐based dose individualization or dose titration is a powerful approach to achieve precision dosing. Yet, titration as an individualization strategy is underused in drug development and therefore not reflected in labeling, possibly partly because of the data analysis challenges associated wit...

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Detalles Bibliográficos
Autores principales: Kristensen, Niels Rode, Agersø, Henrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755917/
https://www.ncbi.nlm.nih.gov/pubmed/36125910
http://dx.doi.org/10.1002/psp4.12863

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