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Chronic hypoxia is associated with transcriptomic reprogramming and increased genomic instability in cancer cells

Hypoxia afflicts the microenvironment of solid tumors fueling malignancy. We investigated the impact of long hypoxia exposure on transcriptional remodeling, tumor mutational burden (TMB), and genomic instability of cancer cells that were grouped based on their inherent sensitivity or resistance to h...

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Detalles Bibliográficos
Autores principales:	Abou Khouzam, Raefa, Sharda, Mohak, Rao, Shyama Prasad, Kyerewah-Kersi, Stephanie Maame, Zeinelabdin, Nagwa Ahmed, Mahmood, Ayda Shah, Nawafleh, Husam, Khan, Munazza Samar, Venkatesh, Goutham Hassan, Chouaib, Salem
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10033758/ https://www.ncbi.nlm.nih.gov/pubmed/36968212 http://dx.doi.org/10.3389/fcell.2023.1095419

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