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Red wine consumption increases antioxidant status and decreases oxidative stress in the circulation of both young and old humans

BACKGROUND: Red wine contains a naturally rich source of antioxidants, which may protect the body from oxidative stress, a determinant of age-related disease. The current study set out to determine the in vivo effects of moderate red wine consumption on antioxidant status and oxidative stress in the...

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Autores principales: Micallef, Michelle, Lexis, Louise, Lewandowski, Paul
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2039729/
https://www.ncbi.nlm.nih.gov/pubmed/17888186
http://dx.doi.org/10.1186/1475-2891-6-27
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author Micallef, Michelle
Lexis, Louise
Lewandowski, Paul
author_facet Micallef, Michelle
Lexis, Louise
Lewandowski, Paul
author_sort Micallef, Michelle
collection PubMed
description BACKGROUND: Red wine contains a naturally rich source of antioxidants, which may protect the body from oxidative stress, a determinant of age-related disease. The current study set out to determine the in vivo effects of moderate red wine consumption on antioxidant status and oxidative stress in the circulation. METHODS: 20 young (18–30 yrs) and 20 older (≥ 50 yrs) volunteers were recruited. Each age group was randomly divided into treatment subjects who consumed 400 mL/day of red wine for two weeks, or control subjects who abstained from alcohol for two weeks, after which they crossed over into the other group. Blood samples were collected before and after red wine consumption and were used for analysis of whole blood glutathione (GSH), plasma malondialdehyde (MDA) and serum total antioxidant status. RESULTS: Results from this study show consumption of red wine induced significant increases in plasma total antioxidant status (P < 0.03), and significant decreases in plasma MDA (P < 0.001) and GSH (P < 0.004) in young and old subjects. The results show that the consumption of 400 mL/day of red wine for two weeks, significantly increases antioxidant status and decreases oxidative stress in the circulation CONCLUSION: It may be implied from this data that red wine provides general oxidative protection and to lipid systems in circulation via the increase in antioxidant status.
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spelling pubmed-20397292007-10-20 Red wine consumption increases antioxidant status and decreases oxidative stress in the circulation of both young and old humans Micallef, Michelle Lexis, Louise Lewandowski, Paul Nutr J Research BACKGROUND: Red wine contains a naturally rich source of antioxidants, which may protect the body from oxidative stress, a determinant of age-related disease. The current study set out to determine the in vivo effects of moderate red wine consumption on antioxidant status and oxidative stress in the circulation. METHODS: 20 young (18–30 yrs) and 20 older (≥ 50 yrs) volunteers were recruited. Each age group was randomly divided into treatment subjects who consumed 400 mL/day of red wine for two weeks, or control subjects who abstained from alcohol for two weeks, after which they crossed over into the other group. Blood samples were collected before and after red wine consumption and were used for analysis of whole blood glutathione (GSH), plasma malondialdehyde (MDA) and serum total antioxidant status. RESULTS: Results from this study show consumption of red wine induced significant increases in plasma total antioxidant status (P < 0.03), and significant decreases in plasma MDA (P < 0.001) and GSH (P < 0.004) in young and old subjects. The results show that the consumption of 400 mL/day of red wine for two weeks, significantly increases antioxidant status and decreases oxidative stress in the circulation CONCLUSION: It may be implied from this data that red wine provides general oxidative protection and to lipid systems in circulation via the increase in antioxidant status. BioMed Central 2007-09-24 /pmc/articles/PMC2039729/ /pubmed/17888186 http://dx.doi.org/10.1186/1475-2891-6-27 Text en Copyright © 2007 Micallef et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Micallef, Michelle
Lexis, Louise
Lewandowski, Paul
Red wine consumption increases antioxidant status and decreases oxidative stress in the circulation of both young and old humans
title Red wine consumption increases antioxidant status and decreases oxidative stress in the circulation of both young and old humans
title_full Red wine consumption increases antioxidant status and decreases oxidative stress in the circulation of both young and old humans
title_fullStr Red wine consumption increases antioxidant status and decreases oxidative stress in the circulation of both young and old humans
title_full_unstemmed Red wine consumption increases antioxidant status and decreases oxidative stress in the circulation of both young and old humans
title_short Red wine consumption increases antioxidant status and decreases oxidative stress in the circulation of both young and old humans
title_sort red wine consumption increases antioxidant status and decreases oxidative stress in the circulation of both young and old humans
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2039729/
https://www.ncbi.nlm.nih.gov/pubmed/17888186
http://dx.doi.org/10.1186/1475-2891-6-27
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