The First α Helix of Interleukin (Il)-2 Folds as a Homotetramer, Acts as an Agonist of the IL-2 Receptor β Chain, and Induces Lymphokine-Activated Killer Cells

Interleukin (IL)-2 interacts with two types of functional receptors (IL-2Rαβγ and IL-2Rβγ) and acts on a broad range of target cells involved in inflammatory reactions and immune responses. For the first time, we show that a chemically synthesized fragment of the IL-2 sequence can fold into a molecu...

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Detalles Bibliográficos
Autores principales: Eckenberg, Ralph, Rose, Thierry, Moreau, Jean-Louis, Weil, Robert, Gesbert, Franck, Dubois, Sigrid, Tello, Diana, Bossus, Marc, Gras, Hélène, Tartar, André, Bertoglio, Jacques, Chouaïb, Salem, Goldberg, Michel, Jacques, Yannick, Alzari, Pedro M., Thèze, Jacques
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195822/
https://www.ncbi.nlm.nih.gov/pubmed/10662798

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