Cargando…

Improved Protective Efficacy of a Species-Specific DNA Vaccine Encoding Mycolyl-Transferase Ag85A from Mycobacterium ulcerans by Homologous Protein Boosting

Vaccination with plasmid DNA encoding Ag85A from M. bovis BCG can partially protect C57BL/6 mice against a subsequent footpad challenge with M. ulcerans. Unfortunately, this cross-reactive protection is insufficient to completely control the infection. Although genes encoding Ag85A from M. bovis BCG...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tanghe, Audrey, Dangy, Jean-Pierre, Pluschke, Gerd, Huygen, Kris
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265439/ https://www.ncbi.nlm.nih.gov/pubmed/18350112 http://dx.doi.org/10.1371/journal.pntd.0000199

Ejemplares similares

The Immunodominant T-Cell Epitopes of the Mycolyl-Transferases of the Antigen 85 Complex of M. tuberculosis
por: Huygen, Kris
Publicado: (2014)

Production and Purification of Mycolyl Transferase B of Mycobacterium tuberculosis
por: Aghababa, Haniyeh, et al.
Publicado: (2011)

T Cell Reactivity against Mycolyl Transferase Antigen 85 of M. tuberculosis in HIV-TB Coinfected Subjects and in AIDS Patients Suffering from Tuberculosis and Nontuberculous Mycobacterial Infections
por: Launois, Pascal, et al.
Publicado: (2011)

Analysis and modeling of mycolyl-transferases in the CMN group
por: Ramulu, Hemalatha Golaconda, et al.
Publicado: (2006)

Structure-Activity Relationship Studies on the Macrolide Exotoxin Mycolactone of Mycobacterium ulcerans
por: Scherr, Nicole, et al.
Publicado: (2013)

Development of an ELISA for the quantification of mycolactone, the cytotoxic macrolide toxin of Mycobacterium ulcerans
por: Warryn, Louisa, et al.
Publicado: (2020)

Efficacy of an Acid-Oxidizing Solution against Mycobacterium ulcerans
por: Warryn, Louisa, et al.
Publicado: (2022)

Antibody-Mediated Neutralization of the Exotoxin Mycolactone, the Main Virulence Factor Produced by Mycobacterium ulcerans
por: Dangy, Jean-Pierre, et al.
Publicado: (2016)

Differential Gene Repertoire in Mycobacterium ulcerans Identifies Candidate Genes for Patho-Adaptation
por: Käser, Michael, et al.
Publicado: (2008)

Ongoing Genome Reduction in Mycobacterium ulcerans
por: Rondini, Simona, et al.
Publicado: (2007)

Mycobacterium ulcerans Mouse Model Refinement for Pre-Clinical Profiling of Vaccine Candidates
por: Bénard, Angèle, et al.
Publicado: (2016)

Evaluating decontamination protocols for the isolation of Mycobacterium ulcerans from swabs
por: Owusu, Enid, et al.
Publicado: (2017)

Use of Recombinant Virus Replicon Particles for Vaccination against Mycobacterium ulcerans Disease
por: Bolz, Miriam, et al.
Publicado: (2015)

Identification of the Mycobacterium ulcerans Protein MUL_3720 as a Promising Target for the Development of a Diagnostic Test for Buruli Ulcer
por: Dreyer, Anita, et al.
Publicado: (2015)

Genomic Diversity and Evolution of Mycobacterium ulcerans Revealed by Next-Generation Sequencing
por: Qi, Weihong, et al.
Publicado: (2009)

Analysis of the Vaccine Potential of Plasmid DNA Encoding Nine Mycolactone Polyketide Synthase Domains in Mycobacterium ulcerans Infected Mice
por: Roupie, Virginie, et al.
Publicado: (2014)

Buruli ulcer: The Efficacy of Innate Immune Defense May Be a Key Determinant for the Outcome of Infection With Mycobacterium ulcerans
por: Röltgen, Katharina, et al.
Publicado: (2020)

Recombinant BCG Expressing Mycobacterium ulcerans Ag85A Imparts Enhanced Protection against Experimental Buruli ulcer
por: Hart, Bryan E., et al.
Publicado: (2015)

Serodiagnostic Efficacy of Mycobacterium tuberculosis 30/32-kDa Mycolyl Transferase Complex, ESAT-6, and CFP-10 in Patients with Active Tuberculosis
por: Kumar, Gavish, et al.
Publicado: (2010)

Buruli Ulcer (M. ulcerans Infection): New Insights, New Hope for Disease Control
por: Johnson, Paul D. R, et al.
Publicado: (2005)

On the origin of Mycobacterium ulcerans, the causative agent of Buruli ulcer
por: Doig, Kenneth D, et al.
Publicado: (2012)

Evolution of two distinct phylogenetic lineages of the emerging human pathogen Mycobacterium ulcerans
por: Käser, Michael, et al.
Publicado: (2007)

Development of a Temperature-Switch PCR-Based SNP Typing Method for Mycobacterium ulcerans
por: Röltgen, Katharina, et al.
Publicado: (2012)

Mycobacterium ulcerans DNA in Bandicoot Excreta in Buruli Ulcer–Endemic Area, Northern Queensland, Australia
por: Röltgen, Katharina, et al.
Publicado: (2017)

Correction: Buruli Ulcer (M. ulcerans Infection): New Insights, New Hope for Disease Control
por: Johnson, Paul D. R, et al.
Publicado: (2005)

A Sero-epidemiological Approach to Explore Transmission of Mycobacterium ulcerans
por: Ampah, Kobina Assan, et al.
Publicado: (2016)

Interferon-γ Is a Crucial Activator of Early Host Immune Defense against Mycobacterium ulcerans Infection in Mice
por: Bieri, Raphael, et al.
Publicado: (2016)

The cell surface protein MUL_3720 confers binding of the skin pathogen Mycobacterium ulcerans to sulfated glycans and keratin
por: Day, Christopher J., et al.
Publicado: (2021)

Sero-Epidemiology as a Tool to Screen Populations for Exposure to Mycobacterium ulcerans
por: Yeboah-Manu, Dorothy, et al.
Publicado: (2012)

Local Cellular Immune Responses and Pathogenesis of Buruli Ulcer Lesions in the Experimental Mycobacterium Ulcerans Pig Infection Model
por: Bolz, Miriam, et al.
Publicado: (2016)

Experimental Infection of the Pig with Mycobacterium ulcerans: A Novel Model for Studying the Pathogenesis of Buruli Ulcer Disease
por: Bolz, Miriam, et al.
Publicado: (2014)

Serological Evaluation of Mycobacterium ulcerans Antigens Identified by Comparative Genomics
por: Pidot, Sacha J., et al.
Publicado: (2010)

Introduction of Mycobacterium ulcerans disease in the Bankim Health District of Cameroon follows damming of the Mapé River
por: Vandelannoote, Koen, et al.
Publicado: (2020)

Spatial Distribution of Mycobacterium ulcerans in Buruli Ulcer Lesions: Implications for Laboratory Diagnosis
por: Ruf, Marie-Thérèse, et al.
Publicado: (2016)

Overexpression of a Mycobacterium ulcerans Ag85B-EsxH Fusion Protein in Recombinant BCG Improves Experimental Buruli Ulcer Vaccine Efficacy
por: Hart, Bryan E., et al.
Publicado: (2016)

Susceptibility to Mycobacterium ulcerans Disease (Buruli ulcer) Is Associated with IFNG and iNOS Gene Polymorphisms
por: Bibert, Stéphanie, et al.
Publicado: (2017)

Mycobacterium ulcerans Persistence at a Village Water Source of Buruli Ulcer Patients
por: Bratschi, Martin W., et al.
Publicado: (2014)

The immunology of other mycobacteria: M. ulcerans, M. leprae
por: Röltgen, Katharina, et al.
Publicado: (2020)

Cellular Immunity Confers Transient Protection in Experimental Buruli Ulcer following BCG or Mycolactone-Negative Mycobacterium ulcerans Vaccination
por: Fraga, Alexandra G., et al.
Publicado: (2012)

Spatiotemporal Co-existence of Two Mycobacterium ulcerans Clonal Complexes in the Offin River Valley of Ghana
por: Lamelas, Araceli, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_t8igff2nel94f96m148d24k7qf