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Capturing Alzheimer's disease genomes with induced pluripotent stem cells: prospects and challenges
A crucial limitation to our understanding of Alzheimer's disease (AD) is the inability to test hypotheses on live, patient-specific neurons. Patient autopsies are limited in supply and only reveal endpoints of disease. Rodent models harboring familial AD mutations lack important pathologies, an...
Autores principales: | Israel, Mason A, Goldstein, Lawrence SB |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221547/ https://www.ncbi.nlm.nih.gov/pubmed/21867573 http://dx.doi.org/10.1186/gm265 |
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