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Ab Initio Modeling and Experimental Assessment of Janus Kinase 2 (JAK2) Kinase-Pseudokinase Complex Structure
The Janus Kinase 2 (JAK2) plays essential roles in transmitting signals from multiple cytokine receptors, and constitutive activation of JAK2 results in hematopoietic disorders and oncogenesis. JAK2 kinase activity is negatively regulated by its pseudokinase domain (JH2), where the gain-of-function...
Autores principales: | Wan, Xiaobo, Ma, Yue, McClendon, Christopher L., Huang, Lily Jun-shen, Huang, Niu |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616975/ https://www.ncbi.nlm.nih.gov/pubmed/23592968 http://dx.doi.org/10.1371/journal.pcbi.1003022 |
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