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Investigating the role of filamin C in Belgian patients with frontotemporal dementia linked to GRN deficiency in FTLD-TDP brains
TAR DNA-binding protein 43 (TDP-43) inclusions are pathological hallmarks of patients with frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). Loss of TDP-43 in zebrafish engenders a severe muscle and vascular phenotype with a concomitant elevation of filamin C (FLNC) l...
Autores principales: | Janssens, Jonathan, Philtjens, Stéphanie, Kleinberger, Gernot, Van Mossevelde, Sara, van der Zee, Julie, Cacace, Rita, Engelborghs, Sebastiaan, Sieben, Anne, Banzhaf-Strathmann, Julia, Dillen, Lubina, Merlin, Céline, Cuijt, Ivy, Robberecht, Caroline, Schmid, Bettina, Santens, Patrick, Ivanoiu, Adrian, Vandenbulcke, Mathieu, Vandenberghe, Rik, Cras, Patrick, De Deyn, Peter P., Martin, Jean-Jacques, Maudsley, Stuart, Haass, Christian, Cruts, Marc, Van Broeckhoven, Christine |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641381/ https://www.ncbi.nlm.nih.gov/pubmed/26555887 http://dx.doi.org/10.1186/s40478-015-0246-7 |
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