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Identification of key factors conquering developmental arrest of somatic cell cloned embryos by combining embryo biopsy and single-cell sequencing
Differentiated somatic cells can be reprogrammed into totipotent embryos through somatic cell nuclear transfer. However, most cloned embryos arrest at early stages and the underlying molecular mechanism remains largely unexplored. Here, we first developed a somatic cell nuclear transfer embryo biops...
Autores principales: | Liu, Wenqiang, Liu, Xiaoyu, Wang, Chenfei, Gao, Yawei, Gao, Rui, Kou, Xiaochen, Zhao, Yanhong, Li, Jingyi, Wu, You, Xiu, Wenchao, Wang, Su, Yin, Jiqing, Liu, Wei, Cai, Tao, Wang, Hong, Zhang, Yong, Gao, Shaorong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897595/ https://www.ncbi.nlm.nih.gov/pubmed/27462457 http://dx.doi.org/10.1038/celldisc.2016.10 |
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