Convenience versus Biological Significance: Are PMA-Differentiated THP-1 Cells a Reliable Substitute for Blood-Derived Macrophages When Studying in Vitro Polarization?

Human peripheral-blood monocytes are used as an established in vitro system for generating macrophages. For several reasons, monocytic cell lines such as THP-1 have been considered as a possible alternative. In view of their distinct developmental origins and phenotypic attributes, we set out to ass...

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Detalles Bibliográficos
Autores principales: Tedesco, Serena, De Majo, Federica, Kim, Jieun, Trenti, Annalisa, Trevisi, Lucia, Fadini, Gian Paolo, Bolego, Chiara, Zandstra, Peter W., Cignarella, Andrea, Vitiello, Libero
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826964/
https://www.ncbi.nlm.nih.gov/pubmed/29520230
http://dx.doi.org/10.3389/fphar.2018.00071

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