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Ubiquitous Presence in Mammalian Cells of Enzymatic Activity Specifically Cleaving 8‐Hydroxyguanine‐containing DNA
Here we report the finding of enzymatic activity that specifically cleaves DNA containing 8‐hydroxyguanine (oh(8)Gua) residues in various mammalian cells. To detect this activity, we used a synthetic double‐stranded DNA containing a single oh(8)Gua at a defined position as the substrate, and analyze...
Autores principales: | Yamamoto, Fuyumi, Kasai, Hiroshi, Bessho, Tadayoshi, Chung, Myung‐Hee, Inoue, Hideo, Ohtsuka, Eiko, Hori, Tomokatsu, Nishimura, Susumu |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
1992
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918833/ https://www.ncbi.nlm.nih.gov/pubmed/1506269 http://dx.doi.org/10.1111/j.1349-7006.1992.tb00114.x |
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