Structure guided fluorescence labeling reveals a two-step binding mechanism of neomycin to its RNA aptamer

The ability of the cytidine analog Ç(m)(f) to act as a position specific reporter of RNA-dynamics was spectroscopically evaluated. Ç(m)(f)-labeled single- and double-stranded RNAs differ in their fluorescence lifetimes, quantum yields and anisotropies. These observables were also influenced by the n...

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Detalles Bibliográficos
Autores principales: Gustmann, Henrik, Segler, Anna-Lena J, Gophane, Dnyaneshwar B, Reuss, Andreas J, Grünewald, Christian, Braun, Markus, Weigand, Julia E, Sigurdsson, Snorri Th, Wachtveitl, Josef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326822/
https://www.ncbi.nlm.nih.gov/pubmed/30462266
http://dx.doi.org/10.1093/nar/gky1110

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326822/
https://www.ncbi.nlm.nih.gov/pubmed/30462266
http://dx.doi.org/10.1093/nar/gky1110

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