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Joint Analysis of Genetic Correlation, Mendelian Randomization and Colocalization Highlights the Bi-Directional Causal Association Between Hypothyroidism and Primary Biliary Cirrhosis
Background: Hypothyroidism and primary biliary cirrhosis (PBC) are often co-existed in observational epidemiological studies. However, the causal relationship between them remains unclear. Methods: Genetic correlation, Mendelian randomization (MR) and colocalization analysis were combined to assess...
Autores principales: | Wang, Yanjun, Guo, Ping, Zhang, Yanan, Liu, Lu, Yan, Ran, Yuan, Zhongshang, Song, Yongfeng |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8521021/ https://www.ncbi.nlm.nih.gov/pubmed/34671386 http://dx.doi.org/10.3389/fgene.2021.753352 |
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