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The in Vivo Toxicity of Hydroxyurea Depends on Its Direct Target Catalase
Hydroxyurea (HU) is a well tolerated ribonucleotide reductase inhibitor effective in HIV, sickle cell disease, and blood cancer therapy. Despite a positive initial response, however, most treated cancers eventually progress due to development of HU resistance. Although RNR properties influence HU re...
Autores principales: | Juul, Trine, Malolepszy, Anna, Dybkær, Karen, Kidmose, Rune, Rasmussen, Jan Trige, Andersen, Gregers Rom, Johnsen, Hans Erik, Jørgensen, Jan-Elo, Andersen, Stig Uggerhøj |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898382/ https://www.ncbi.nlm.nih.gov/pubmed/20452979 http://dx.doi.org/10.1074/jbc.M110.103564 |
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