Cargando…

Probing Lactate Dehydrogenase Activity in Tumors by Measuring Hydrogen/Deuterium Exchange in Hyperpolarized l-[1-(13)C,U-(2)H]Lactate

[Image: see text] (13)C magnetic resonance spectroscopy and spectroscopic imaging measurements of hyperpolarized (13)C label exchange between exogenously administered [1-(13)C]pyruvate and endogenous lactate, catalyzed by lactate dehydrogenase (LDH), has proved to be a powerful approach for probing...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kennedy, Brett W. C., Kettunen, Mikko I., Hu, De-En, Brindle, Kevin M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2012
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303201/ https://www.ncbi.nlm.nih.gov/pubmed/22316419 http://dx.doi.org/10.1021/ja300222e

Ejemplares similares

Hyperpolarized [1-(13)C]-Ascorbic and Dehydroascorbic Acid: Vitamin C as a Probe for Imaging Redox Status in Vivo
por: Bohndiek, Sarah E., et al.
Publicado: (2011)

Magnetic resonance imaging of tumor glycolysis using hyperpolarized (13)C-labeled glucose
por: Rodrigues, Tiago B., et al.
Publicado: (2013)

Increased hyperpolarized [1‐(13)C] lactate production in a model of joint inflammation is not accompanied by tissue acidosis as assessed using hyperpolarized (13)C‐labelled bicarbonate
por: Wright, Alan J., et al.
Publicado: (2018)

A referenceless Nyquist ghost correction workflow for echo planar imaging of hyperpolarized [1‐(13)C]pyruvate and [1‐(13)C]lactate
por: Wang, Jiazheng, et al.
Publicado: (2017)

Effects of fasting on serial measurements of hyperpolarized [1‐(13)C]pyruvate metabolism in tumors
por: Serrao, Eva M., et al.
Publicado: (2016)

Dynamic (1)H imaging of hyperpolarized [1‐(13)C]lactate in vivo using a reverse INEPT experiment
por: Wang, Jiazheng, et al.
Publicado: (2017)

Assessing Oxidative Stress in Tumors by Measuring the Rate of Hyperpolarized [1-(13)C]Dehydroascorbic Acid Reduction Using (13)C Magnetic Resonance Spectroscopy
por: Timm, Kerstin N., et al.
Publicado: (2017)

Comparison of (13)C MRI of hyperpolarized [1‐(13)C]pyruvate and lactate with the corresponding mass spectrometry images in a murine lymphoma model
por: Fala, Maria, et al.
Publicado: (2021)

Dynamic Imaging of Glucose and Lactate Metabolism by (13)C-MRS without Hyperpolarization
por: Brender, Jeffrey R., et al.
Publicado: (2019)

Toward Optimizing and Understanding Reversible Hyperpolarization of Lactate Esters Relayed from para-Hydrogen
por: Tickner, Ben J., et al.
Publicado: (2022)

Hyperpolarized Carbon-13 MRI in Breast Cancer
por: Woitek, Ramona, et al.
Publicado: (2023)

Hyperpolarized [1-13C]lactate flux increased in the hippocampal region in diabetic mice
por: Choi, Young-Suk, et al.
Publicado: (2019)

Lactate saturation limits bicarbonate detection in hyperpolarized (13)C‐pyruvate MRI of the brain
por: Bøgh, Nikolaj, et al.
Publicado: (2022)

Probing hepatic metabolism of [2-(13)C]dihydroxyacetone in vivo with (1)H-decoupled hyperpolarized (13)C-MR
por: Marco-Rius, Irene, et al.
Publicado: (2020)

(13)C magnetic resonance spectroscopy measurements with hyperpolarized [1‐(13)C] pyruvate can be used to detect the expression of transgenic pyruvate decarboxylase activity in vivo
por: Dzien, Piotr, et al.
Publicado: (2015)

Hydrogen-Deuterium Exchange Profiles of Polyubiquitin Fibrils
por: Morimoto, Daichi, et al.
Publicado: (2018)

Lactate Dehydrogenase-Elevating Virus
por: Coutelier, Jean-Paul, et al.
Publicado: (2007)

Lactate Dehydrogenase: The Beacon of Hope?
por: Pandarathodiyil, Anitha Krishnan, et al.
Publicado: (2022)

Histidine Hydrogen-Deuterium Exchange Mass Spectrometry for Probing the Microenvironment of Histidine Residues in Dihydrofolate Reductase
por: Miyagi, Masaru, et al.
Publicado: (2011)

Quantitation of a spin polarization-induced nuclear Overhauser effect (SPINOE) between a hyperpolarized (13)C-labeled cell metabolite and water protons
por: Marco-Rius, Irene, et al.
Publicado: (2014)

Natural compounds as lactate dehydrogenase inhibitors: potential therapeutics for lactate dehydrogenase inhibitors-related diseases
por: Han, Jung Ho, et al.
Publicado: (2023)

Single shot three‐dimensional pulse sequence for hyperpolarized (13)C MRI
por: Wang, Jiazheng, et al.
Publicado: (2016)

Hyperpolarized (13)C Diffusion MRS of Co-Polarized Pyruvate and Fumarate to Measure Lactate Export and Necrosis
por: Feuerecker, Benedikt, et al.
Publicado: (2017)

Sensitive, Efficient and Portable Analysis of Molecular Exchange Processes by Hyperpolarized Ultrafast NMR
por: Kharbanda, Yashu, et al.
Publicado: (2022)

Imaging Glioblastoma Metabolism by Using Hyperpolarized [1-(13)C]Pyruvate Demonstrates Heterogeneity in Lactate Labeling: A Proof of Principle Study
por: Zaccagna, Fulvio, et al.
Publicado: (2022)

Glyoxalase activity in human erythrocytes and mouse lymphoma, liver and brain probed with hyperpolarized (13)C-methylglyoxal
por: Shishmarev, Dmitry, et al.
Publicado: (2018)

The mitochondrial L-lactate dehydrogenase affair
por: Passarella, Salvatore, et al.
Publicado: (2014)

Lactate dehydrogenase, COVID-19 and mortality
por: Bartziokas, Konstantinos, et al.
Publicado: (2021)

Lactate dehydrogenase, COVID-19 and mortality
por: Bartziokas, Konstantinos, et al.
Publicado: (2021)

l-Lactate treatment by photosynthetic cyanobacteria expressing heterogeneous l-lactate dehydrogenase
por: Kato, Yuichi, et al.
Publicado: (2023)

The Role of Lactate Metabolism in Prostate Cancer Progression and Metastases Revealed by Dual-Agent Hyperpolarized (13)C MRSI
por: Bok, Robert, et al.
Publicado: (2019)

Offset of apparent hyperpolarized (13)C lactate flux by the use of adjuvant metformin in ionizing radiation therapy in vivo
por: Choi, Young‐Suk, et al.
Publicado: (2021)

Potential Clinical Roles for Metabolic Imaging with Hyperpolarized [1-(13)C]Pyruvate
por: Serrao, Eva M., et al.
Publicado: (2016)

Detecting tumor responses to treatment using hyperpolarized (13)C magnetic resonance spectroscopic imaging
por: Brindle, Kevin M
Publicado: (2010)

Applications of Hydrogen/Deuterium Exchange MS from 2012 to 2014
por: Pirrone, Gregory F., et al.
Publicado: (2014)

Preparation of Deuterium-Labeled Armodafinil by Hydrogen–Deuterium Exchange and Its Application in Quantitative Analysis by LC-MS
por: Grocholska, Paulina, et al.
Publicado: (2022)

Hydrogen/Deuterium Exchange Mass Spectrometry for Probing the Isomeric Forms of Oleocanthal and Oleacin in Extra Virgin Olive Oils
por: Abbattista, Ramona, et al.
Publicado: (2023)

Lactate production yield from engineered yeasts is dependent from the host background, the lactate dehydrogenase source and the lactate export
por: Branduardi, Paola, et al.
Publicado: (2006)

Analysis of (13)C and (14)C labeling in pyruvate and lactate in tumor and blood of lymphoma‐bearing mice injected with (13)C‐ and (14)C‐labeled pyruvate
por: Serrao, E.M., et al.
Publicado: (2018)

H-2-controlled suppression of T cell response to lactate dehydrogenase B. Characterization of the lactate dehydrogenase B suppressor pathway
Publicado: (1982)

Cannot write session to /tmp/vufind_sessions/sess_c87lvh832e2tj5dutnnt519mrl