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A Combination of Screening and Computational Approaches for the Identification of Novel Compounds That Decrease Mast Cell Degranulation
High-content screening of compound libraries poses various challenges in the early steps in drug discovery such as gaining insights into the mode of action of the selected compounds. Here, we addressed these challenges by integrating two biological screens through bioinformatics and computational an...
Autores principales: | McShane, Marisa P., Friedrichson, Tim, Giner, Angelika, Meyenhofer, Felix, Barsacchi, Rico, Bickle, Marc, Zerial, Marino |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512528/ https://www.ncbi.nlm.nih.gov/pubmed/25838434 http://dx.doi.org/10.1177/1087057115579613 |
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