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Redirection of CD4+ and CD8+ T lymphocytes via an anti-CD3 × anti-CD19 bi-specific antibody combined with cytosine arabinoside and the efficient lysis of patient-derived B-ALL cells

BACKGROUND: B-acute lymphoblastic leukemia (B-ALL) is derived from B cell progenitors. Recently, the development of appropriate combinations of chemotherapy and immunotherapy represents a promising approach for eliminating cancer. We previously constructed an anti-CD3 × anti-CD19 bi-specific antibod...

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Detalles Bibliográficos
Autores principales:	Fan, Dongmei, Li, Wei, Yang, Yuqi, Zhang, Xiaolong, Zhang, Qing, Yan, Yan, Yang, Ming, Wang, Jianxiang, Xiong, Dongsheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596481/ https://www.ncbi.nlm.nih.gov/pubmed/26444983 http://dx.doi.org/10.1186/s13045-015-0205-6

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