Cargando…

Relevance of Sp Binding Site Polymorphism in WWOX for Treatment Outcome in Pancreatic Cancer

BACKGROUND: A genome-wide association study (GWAS) suggested inherited genetic single-nucleotide polymorphisms (SNPs) affecting overall survival (OS) in advanced pancreatic cancer. To identify robust clinical biomarkers, we tested the strongest reported candidate loci in an independent patient cohor...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schirmer, Markus A., Lüske, Claudia M., Roppel, Sebastian, Schaudinn, Alexander, Zimmer, Christian, Pflüger, Ruben, Haubrock, Martin, Rapp, Jacobe, Güngör, Cenap, Bockhorn, Maximilian, Hackert, Thilo, Hank, Thomas, Strobel, Oliver, Werner, Jens, Izbicki, Jakob R., Johnsen, Steven A., Gaedcke, Jochen, Brockmöller, Jürgen, Ghadimi, B. Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859408/ https://www.ncbi.nlm.nih.gov/pubmed/26857392 http://dx.doi.org/10.1093/jnci/djv387

Ejemplares similares

Unmasking metabolic dependencies in pancreatic cancer: aberrant polyamine synthesis as a promising new therapeutic target
por: Wolters-Eisfeld, Gerrit, et al.
Publicado: (2023)

Loss of complex O-glycosylation impairs exocrine pancreatic function and induces MODY8-like diabetes in mice
por: Wolters-Eisfeld, Gerrit, et al.
Publicado: (2018)

Neonatal neuronal WWOX gene therapy rescues Wwox null phenotypes
por: Repudi, Srinivasarao, et al.
Publicado: (2021)

Establishment and characterization of a new human pancreatic adenocarcinoma cell line with high metastatic potential to the lung
por: Kalinina, Tatyana, et al.
Publicado: (2010)

COSMC knockdown mediated aberrant O-glycosylation promotes oncogenic properties in pancreatic cancer
por: Hofmann, Bianca T., et al.
Publicado: (2015)

WWOX Possesses N-Terminal Cell Surface-Exposed Epitopes WWOX(7-21) and WWOX(7-11) for Signaling Cancer Growth Suppression and Prevention In Vivo
por: Wang, Wan-Jen, et al.
Publicado: (2019)

Potential role of the bitter taste receptor T2R14 in the prolonged survival and enhanced chemoresponsiveness induced by apigenin
por: Stern, Louisa, et al.
Publicado: (2022)

WWOX Phosphorylation, Signaling, and Role in Neurodegeneration
por: Liu, Chan-Chuan, et al.
Publicado: (2018)

WWOX loss activates aerobic glycolysis
por: Abu-Remaileh, Muhannad, et al.
Publicado: (2014)

The WWOX gene in brain development and pathology
por: Kośla, K, et al.
Publicado: (2020)

WWOX and Its Binding Proteins in Neurodegeneration
por: Hsu, Che-Yu, et al.
Publicado: (2021)

CXCR7 expression in esophageal cancer
por: Tachezy, Michael, et al.
Publicado: (2013)

ALCAM (CD166) Expression and Serum Levels in Pancreatic Cancer
por: Tachezy, Michael, et al.
Publicado: (2012)

Normal cells repel WWOX-negative or -dysfunctional cancer cells via WWOX cell surface epitope 286-299
por: Chen, Yu-An, et al.
Publicado: (2021)

Decreased WWOX expression promotes angiogenesis in osteosarcoma
por: Wen, Jia, et al.
Publicado: (2017)

WWOX guards genome stability by activating ATM
por: Hazan, Idit, et al.
Publicado: (2015)

WWOX Loss of Function in Neurodevelopmental and Neurodegenerative Disorders
por: Aldaz, C. Marcelo, et al.
Publicado: (2020)

WWOX and metabolic regulation in normal and pathological conditions
por: Baryła, Izabela, et al.
Publicado: (2022)

Minimally invasive surgery for colorectal cancer remains underutilized in Germany despite its nationwide application over the last decade
por: Ghadban, Tarik, et al.
Publicado: (2018)

NOTCH Activation via gp130/STAT3 Signaling Confers Resistance to Chemoradiotherapy
por: Koerdel, Kristin, et al.
Publicado: (2021)

8-Oxoguanine DNA Glycosylase (OGG1) Cys326 Variant: Increased Risk for Worse Outcome of Patients with Locally Advanced Rectal Cancer after Multimodal Therapy
por: Leu, Martin, et al.
Publicado: (2021)

Tenascin-C serum levels and its prognostic power in non-small cell lung cancer
por: Gebauer, Florian, et al.
Publicado: (2016)

WWOX gene is associated with HDL cholesterol and triglyceride levels
por: Sáez, María E, et al.
Publicado: (2010)

Expression of WW domain–containing oxidoreductase WWOX in pterygium
por: Huang, Yi-Hsun, et al.
Publicado: (2015)

WWOX rs11644322 Polymorphism, Gemcitabine, and Pancreatic Cancer
por: Yasri, Sora, et al.
Publicado: (2017)

Correlation between osteosarcoma and the expression of WWOX and p53
por: Liu, Pingtao, et al.
Publicado: (2017)

Pleiotropic tumor suppressor functions of WWOX antagonize metastasis
por: Khawaled, Saleh, et al.
Publicado: (2020)

WWOX-Related Neurodevelopmental Disorders: Models and Future Perspectives
por: Steinberg, Daniel J., et al.
Publicado: (2021)

Molecular Functions of WWOX Potentially Involved in Cancer Development
por: Taouis, Karim, et al.
Publicado: (2021)

WWOX Modulates ROS-Dependent Senescence in Bladder Cancer
por: Liu, Ching-Wen, et al.
Publicado: (2022)

Heterogeneity of KRAS Mutation Status in Rectal Cancer
por: Jo, Peter, et al.
Publicado: (2016)

KRAS mutation status concordance between the primary tumor and the corresponding metastasis in patients with rectal cancer
por: Jo, Peter, et al.
Publicado: (2020)

Strategies by which WWOX-deficient metastatic cancer cells utilize to survive via dodging, compromising, and causing damage to WWOX-positive normal microenvironment
por: Chou, Pei-Yi, et al.
Publicado: (2019)

Hamburg-Glasgow classification: preoperative staging by combination of disseminated tumour load and systemic inflammation in oesophageal carcinoma
por: Reeh, Matthias, et al.
Publicado: (2017)

LINC01137/miR-186-5p/WWOX: a novel axis identified from WWOX-related RNA interactome in bladder cancer
por: Kołat, Damian, et al.
Publicado: (2023)

Sequential neoadjuvant chemoradiotherapy (CRT) followed by curative surgery vs. primary surgery alone for resectable, non-metastasized pancreatic adenocarcinoma: NEOPA- a randomized multicenter phase III study (NCT01900327, DRKS00003893, ISRCTN82191749)
por: Tachezy, Michael, et al.
Publicado: (2014)

Carcinoembryonic Antigen-Related Cell Adhesion Molecules (CEACAM) 1, 5 and 6 as Biomarkers in Pancreatic Cancer
por: Gebauer, Florian, et al.
Publicado: (2014)

Decentralized colorectal cancer care in Germany over the last decade is associated with high in-hospital morbidity and mortality
por: Ghadban, Tarik, et al.
Publicado: (2019)

WWOX modulates the ATR-mediated DNA damage checkpoint response
por: Abu-Odeh, Mohammad, et al.
Publicado: (2015)

Role of WWOX and NF-κB in lung cancer progression
por: Chen, Szu-Jung, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_giv935nnk0n6js60adoce2fedi