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Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons

BACKGROUND: The protease BACE1 (beta-site APP cleaving enzyme) is a major drug target in Alzheimer’s disease. However, BACE1 therapeutic inhibition may cause unwanted adverse effects due to its additional functions in the nervous system, such as in myelination and neuronal connectivity. Additionally...

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Detalles Bibliográficos
Autores principales:	Pigoni, Martina, Wanngren, Johanna, Kuhn, Peer-Hendrik, Munro, Kathryn M., Gunnersen, Jenny M., Takeshima, Hiroshi, Feederle, Regina, Voytyuk, Iryna, De Strooper, Bart, Levasseur, Mikail D., Hrupka, Brian J., Müller, Stephan A., Lichtenthaler, Stefan F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053352/ https://www.ncbi.nlm.nih.gov/pubmed/27716410 http://dx.doi.org/10.1186/s13024-016-0134-z

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