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TGFBR2-dependent alterations of exosomal cargo and functions in DNA mismatch repair-deficient HCT116 colorectal cancer cells
BACKGROUND: Colorectal cancers (CRCs) that lack DNA mismatch repair function exhibit the microsatellite unstable (MSI) phenotype and are characterized by the accumulation of frameshift mutations at short repetitive DNA sequences (microsatellites). These tumors recurrently show inactivating frameshif...
Autores principales: | Fricke, Fabia, Lee, Jennifer, Michalak, Malwina, Warnken, Uwe, Hausser, Ingrid, Suarez-Carmona, Meggy, Halama, Niels, Schnölzer, Martina, Kopitz, Jürgen, Gebert, Johannes |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379773/ https://www.ncbi.nlm.nih.gov/pubmed/28376875 http://dx.doi.org/10.1186/s12964-017-0169-y |
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