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Integrin beta 1 inhibition alleviates the chronic hyperproliferative dermatitis phenotype of SHARPIN-deficient mice

SHARPIN (Shank-Associated RH Domain-Interacting Protein) is a component of the linear ubiquitin chain assembly complex (LUBAC), which enhances TNF-induced NF-κB activity. SHARPIN-deficient (Sharpin(cpdm/cpdm)) mice display multi-organ inflammation and chronic proliferative dermatitis (cpdm) due to T...

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Detalles Bibliográficos
Autores principales:	Peuhu, Emilia, Salomaa, Siiri I., De Franceschi, Nicola, Potter, Christopher S., Sundberg, John P., Pouwels, Jeroen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645136/ https://www.ncbi.nlm.nih.gov/pubmed/29040328 http://dx.doi.org/10.1371/journal.pone.0186628

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