Direct impact of cisplatin on mitochondria induces ROS production that dictates cell fate of ovarian cancer cells

Patients with high-grade serous ovarian cancer (HGSC) frequently receive platinum-based chemotherapeutics, such as cisplatin. Cisplatin binds to DNA and induces DNA-damage culminating in mitochondria-mediated apoptosis. Interestingly, mitochondrial DNA is critically affected by cisplatin but its rel...

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Detalles Bibliográficos
Autores principales: Kleih, Markus, Böpple, Kathrin, Dong, Meng, Gaißler, Andrea, Heine, Simon, Olayioye, Monilola A., Aulitzky, Walter E., Essmann, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838053/
https://www.ncbi.nlm.nih.gov/pubmed/31699970
http://dx.doi.org/10.1038/s41419-019-2081-4

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