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Substantially improving the enantioconvergence of PvEH1, a Phaseolus vulgaris epoxide hydrolase, towards m-chlorostyrene oxide by laboratory evolution
BACKGROUND: Epoxide hydrolase can regioselectively catalyze the oxirane ring-opening hydrolysis of rac-epoxides producing the corresponding chiral diols. In our laboratory, a gene named pveh1 encoding an EH from Phaseolus vulgaris was cloned. Although the directed modification of PvEH1 was carried o...
Autores principales: | Zong, Xun-Cheng, Li, Chuang, Xu, Yao-Hui, Hu, Die, Hu, Bo-Chun, Zang, Jia, Wu, Min-Chen |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859628/ https://www.ncbi.nlm.nih.gov/pubmed/31739786 http://dx.doi.org/10.1186/s12934-019-1252-4 |
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