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Patisiran Pharmacokinetics, Pharmacodynamics, and Exposure‐Response Analyses in the Phase 3 APOLLO Trial in Patients With Hereditary Transthyretin‐Mediated (hATTR) Amyloidosis
Hereditary transthyretin‐mediated (hATTR) amyloidosis is an inherited, rapidly progressive, life‐threatening disease caused by deposition of abnormal transthyretin protein. Patisiran is an RNA interference therapeutic comprising a novel, small interfering ribonucleic acid (ALN‐18328) formulated in a...
Autores principales: | Zhang, Xiaoping, Goel, Varun, Attarwala, Husain, Sweetser, Marianne T., Clausen, Valerie A., Robbie, Gabriel J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972979/ https://www.ncbi.nlm.nih.gov/pubmed/31322739 http://dx.doi.org/10.1002/jcph.1480 |
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