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Dectin-1 Stimulation of Hematopoietic Stem and Progenitor Cells Occurs In Vivo and Promotes Differentiation Toward Trained Macrophages via an Indirect Cell-Autonomous Mechanism
Toll-like receptor (TLR) agonists drive hematopoietic stem and progenitor cells (HSPCs) to differentiate along the myeloid lineage. In this study, we used an HSPC transplantation model to investigate the possible direct interaction of β-glucan and its receptor (dectin-1) on HSPCs in vivo. Purified H...
Autores principales: | Bono, Cristina, Martínez, Alba, Megías, Javier, Gozalbo, Daniel, Yáñez, Alberto, Gil, M. Luisa |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315119/ https://www.ncbi.nlm.nih.gov/pubmed/32576672 http://dx.doi.org/10.1128/mBio.00781-20 |
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