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ABCB1 Does Not Require the Side-Chain Hydrogen-Bond Donors Gln(347), Gln(725), Gln(990) to Confer Cellular Resistance to the Anticancer Drug Taxol
The multidrug efflux transporter ABCB1 is clinically important for drug absorption and distribution and can be a determinant of chemotherapy failure. Recent structure data shows that three glutamines donate hydrogen bonds to coordinate taxol in the drug binding pocket. This is consistent with earlie...
Autores principales: | Sasitharan, Keerthana, Iqbal, Hamzah Asad, Bifsa, Foteini, Olszewska, Aleksandra, Linton, Kenneth J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395328/ https://www.ncbi.nlm.nih.gov/pubmed/34445264 http://dx.doi.org/10.3390/ijms22168561 |
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