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Rational design of a genome‐based insulated system in Escherichia coli facilitates heterologous uricase expression for hyperuricemia treatment

Hyperuricemia is a prevalent disease worldwide that is characterized by elevated urate levels in the blood owing to purine metabolic disorders, which can result in gout and comorbidities. To facilitate the treatment of hyperuricemia through the uricolysis, we engineered a probiotic Escherichia coli...

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Detalles Bibliográficos
Autores principales:	He, Lina, Tang, Wei, Huang, Ling, Zhou, Wei, Huang, Shaojia, Zou, Linxuan, Yuan, Lisha, Men, Dong, Chen, Shiyun, Hu, Yangbo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013758/ https://www.ncbi.nlm.nih.gov/pubmed/36925686 http://dx.doi.org/10.1002/btm2.10449

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