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Proteomics-based Identification of Novel Factor Inhibiting Hypoxia-inducible Factor (FIH) Substrates Indicates Widespread Asparaginyl Hydroxylation of Ankyrin Repeat Domain-containing Proteins
Post-translational hydroxylation has been considered an unusual modification on intracellular proteins. However, following the recognition that oxygen-sensitive prolyl and asparaginyl hydroxylation are central to the regulation of the transcription factor hypoxia-inducible factor (HIF), interest has...
Autores principales: | Cockman, Matthew E., Webb, James D., Kramer, Holger B., Kessler, Benedikt M., Ratcliffe, Peter J. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649815/ https://www.ncbi.nlm.nih.gov/pubmed/18936059 http://dx.doi.org/10.1074/mcp.M800340-MCP200 |
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